SKU: 91744262575

ICAM-1/CD54 His Tag Protein, Mouse

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Description

ICAM-1/CD54 His Tag Protein, MouseProduct Specification Species Mouse Synonyms BB2, ICAM1, CD54, P3. 58 Accession P13597 1 Amino Acid Sequence Gln28 Asn485, with C 8*His Expression System HEK293 Molecular Weight 72 95kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.

Product Specification


Species Mouse
Synonyms BB2, ICAM1, CD54, P3.58
Accession P13597-1
Amino Acid Sequence Gln28-Asn485, with C-8*His
Expression System HEK293
Molecular Weight 72-95kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1、Gu H F. et al. (2013) Association of intercellular adhesion molecule 1 (ICAM1) with diabetes and diabetic nephropathy. Front Endocrinol. 3: 179.

2、 Williams M R. et al. (2013) ICAM1 ligation‐induced transmigratory complex formation regulates leukocyte transendothelial migration. FASEB J. 27(S1): 57.5-57.5.

Background

ICAM-1 is a cell surface glycoprotein expressed at a low basal level in immune, endothelial (EC) and epithelial cells, but is up-regulated in response to inflammatory stimulation. The function of ICAM-1 has been best studied in leukocyte transendothelial migration (TEM), where ICAM-1 regulates leukocyte rolling and adhesive interactions with the vessel wall, and guides leukocyte crossing of the endothelial layer. More recently, functional studies identified several new roles of ICAM-1 in epithelial injury-resolution responses, innate and adaptive immune responses in inflammation, and tumorigenesis.
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SKU: 91744262575

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