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Description
Alexa Fluor® 647 Rat Anti-Mouse CD39 Antibody (S-R641)Product Specification Host Rat Antigen CD39 Synonyms Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ATP diphosphohydrolase (ATP DPH; ATPDase); Ecto ATP diphosphohydrolase 1 (Ecto ATPDase 1; Ecto ATPase 1); Ecto apyrase; Lymphoid cell activation antigen; Nucleoside triphosphate diphosphohydrolase 1 (NTPDase1); Entpd1 Location Membrane Accession P55772 Clone Number S R641 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms
Product Specification
| Host | Rat |
| Antigen | CD39 |
| Synonyms | Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; ATP diphosphohydrolase (ATP-DPH; ATPDase); Ecto-ATP diphosphohydrolase 1 (Ecto-ATPDase 1; Ecto-ATPase 1); Ecto-apyrase; Lymphoid cell activation antigen; Nucleoside triphosphate diphosphohydrolase 1 (NTPDase1); Entpd1 |
| Location | Membrane |
| Accession | P55772 |
| Clone Number | S-R641 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein G |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD39, also known as ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), is a membrane-bound enzyme that hydrolyzes extracellular nucleotides such as ATP and ADP into AMP in a Ca²⁺- and Mg²⁺-dependent manner. It plays a crucial role in regulating immune responses and vascular function. In the tumor microenvironment, CD39 works with CD73 to convert ATP into adenosine, an immunosuppressive molecule that inhibits the activity of effector immune cells while promoting the function of regulatory immune cells, thus contributing to tumor immune evasion. This protein is highly expressed in various cell types within the tumor microenvironment, including tumor cells, stromal cells, endothelial cells, and immune cells. CD39 is also involved in thromboregulation and has been identified as a potential therapeutic target for cancer immunotherapy.
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